The following Rotary clubs are located in Mainz:

• Rotary Club Mainz
• Rotary Club Mainz 50° North
• Rotary Club Mainz-Churmeyntz
• Rotary Club Mainz Aurea Moguntia
• Rotary Club Mainz-Rheinhessen

The club's members want to combat hardship and poverty through their own projects, provide career counseling and other projects for young people, and promote international youth exchange and international understanding. The clubs are therefore involved in social, professional, and cultural projects at the regional, national, and international levels.